Where to stay: The brand-new Fisher Inn Resort & Marina embraces the heart of life in Islamorada. At this low-rise hotel right on the water, bright turquoise and natural-wood rooms run at less than $200/night and come with a range of modern amenities, including walk-in showers, kitchenettes, refrigerators, Keurig coffee machines, dining areas, a 50” HDTV, blackout screens, and balconies with direct views of those famous Florida Keys sunsets.